About Thorne Advanced Digestive Enzymes Dietary Supplement

Thorne Advanced Digestive Enzymes (formerly Bio-Gest®) is a broad-spectrum digestive enzyme supplement designed to support the optimal digestion of proteins, fats, and carbohydrates throughout the entire digestive process. The formula combines four key digestive agents — betaine hydrochloride (HCl), pepsin, pancreatin, and ox bile — each playing a distinct role at different stages of digestion. Illness, gallbladder removal, overuse of antacids, and the natural aging process can all contribute to insufficient production of stomach acid, pancreatic enzymes, and bile, leading to symptoms such as heartburn, gas, bloating, and other forms of digestive discomfort. Thorne Advanced Digestive Enzymes provides targeted support for individuals who need more than HCl alone — particularly those requiring comprehensive support for protein and carbohydrate digestion as well as fat emulsification and absorption. Beyond digestion, HCl supports the absorption of a broad range of key nutrients including folate, vitamin B12, vitamin C, beta-carotene, and minerals such as iron, calcium, magnesium, and zinc. Pancreatic enzymes and ox bile further support the absorption of fat-soluble nutrients including vitamins A, D, E, and K, CoQ10, and omega-3 fatty acids. Third-party certified, gluten-free, and dairy-free. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content.

Key Benefits & Features

• Comprehensive Multi-Enzyme Formula: Combines betaine hydrochloride (HCl), pepsin, pancreatin, and ox bile to provide broad-spectrum digestive support across all stages of the digestive process — from stomach acid production through fat emulsification and nutrient absorption in the small intestine.
• HCl and Pepsin for Stomach-Phase Digestion: Betaine HCl helps establish the acidic stomach environment necessary for protein breakdown and activation of other digestive enzymes. Pepsin works alongside HCl to initiate the breakdown of dietary proteins into smaller peptides for further digestion downstream.
• Pancreatin for Broad Macronutrient Digestion: Pancreatin is a porcine-derived blend of pancreatic enzymes — including protease, lipase, and amylase — that supports the digestion of proteins, fats, and carbohydrates in the small intestine, providing coverage across all three macronutrient categories.
• Ox Bile for Fat Emulsification and Absorption: Ox bile concentrate supports fat emulsification and the absorption of fat-soluble nutrients — including vitamins A, D, E, and K, CoQ10, and omega-3 fatty acids — which is especially important for individuals who have had their gallbladder removed and can no longer store and release bile on demand.
• Supports Nutrient Absorption: HCl promotes absorption of folate, vitamin B12, vitamin C, beta-carotene, iron, and various forms of calcium, magnesium, and zinc — nutrients whose absorption is directly dependent on adequate stomach acid levels.
• Benefits Individuals with Specific Digestive Challenges: Particularly beneficial for those experiencing occasional indigestion, food sensitivities, post-gallbladder removal digestive issues, age-related decline in digestive enzyme production, or symptoms related to overuse of antacids, H2 blockers, or proton pump inhibitors.
• Undiluted Pepsin and Pancreatin: Unlike some competing formulas, Thorne Advanced Digestive Enzymes contains undiluted pepsin and pancreatin — the formula does not use lactose as a diluent, which is commonly added to pepsin and pancreatin products to extend or reduce potency.
• Third-Party Certified, Gluten-Free, and Dairy-Free: Thorne is one of a select few supplement companies with an NSF Certified for Sport® manufacturing facility. Products are rigorously tested for purity and potency. Thorne is also the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content.

Who Should Be Using This?

Thorne Advanced Digestive Enzymes is appropriate for adults who experience occasional indigestion, bloating, gas, or digestive discomfort — particularly after meals heavy in fat or protein — and for those whose digestive enzyme production may be compromised due to age, gallbladder removal, overuse of antacids, or other contributing factors. This product is contraindicated in individuals with peptic ulcers or a history of hypersensitivity to any of its ingredients. Pregnant women and individuals taking H2-blocking drugs or proton pump inhibitors should consult a healthcare provider before use. Intended for occasional use — consult a healthcare professional for use beyond 4 weeks.

How Do You Use or Apply This Product?

Take 1 to 2 capsules with each meal or as recommended by your healthcare practitioner. Do not remove the powder from the capsule to take orally — the contents can be irritating to the oral mucosa. Do not exceed the recommended dose. This product is contraindicated in patients with peptic ulcers and should not be used concurrently with H2-blocking drugs or proton pump inhibitors.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.